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Welcome to the public TSEs in goats website |
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New paper on goat PrP polymorphisms association |
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Written by Alex Bossers
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Friday, 02 December 2011 11:06 |
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A new publication is out by Goldmann et al. in Veterinary Research that originated from this project on "the association of goat PrP polymorphisms with decreased scrapie susceptibility in UK goat breeds". A collaborative study with contributors from the UK, Mexico, and NL. The paper describes/supports the association of Met142 with decreased susceptibility to scrapie in goats and the suppresive effect of Ser127 on the clinical expression of disease. |
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Prion protein allele frequencies in Europe |
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Written by Jan Langeveld
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Tuesday, 25 October 2011 21:57 |
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One of the tasks of the GoatBSE project has been to study the PrP coding region variation in order to evaluate the presence of alleles which influence the susceptibility of goats to TSE. Several caprine PrP polymorphisms have been published, the most common of which are in codons 142, 154, 211, 222 and 240 (see figures below). It is likely that analysing a larger number of samples from EU breeds would reveal further polymorphisms. We therefore collected samples for analysing the PrP coding region of roughly 6000 samples. These samples originated from several countries, collected from the most common breeds (eg. Saanen, Alpine) as well as some rare goat breeds. Genomic DNA was produced from blood/tissue samples. The PrP coding region was sequenced in full by direct sequencing of PCR-generated DNA.
The results are displayed in the pdf file. If you are using these data, please refer to EU project GoatBSE FOOD-CT-2006-36353, coordinator Alex Bossers, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands. |
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Prion2012 conference registration open! |
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Written by Alex Bossers
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Tuesday, 22 November 2011 23:55 |
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The Prion2012 international conference 9-12 May 2012 registration is now open. The conference will be hosted in Amsterdam the Netherlands. Come and join us to make this a wonderful event; register now at www.prion2012.com
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| As in the previous years, there will be again a pre-conference workshop dedicated to Animal TSEs. |
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List of goat TSE related publications |
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Written by administrator
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Sunday, 08 August 2010 15:57 |
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Goat TSE literature
The history about goat TSEs research started probably in France with a publication from Chelle in 1942. Since then experimental and field have been ongoing regularly in the goat species. The website has prepared an overview of scientific and political documents. If you have new information that would fit in this list, you are wlecome to let the webmaster know, and it will be included. Since May 2011 there have been added over 10 papers to the list. It appears from the scientific papers that the interest for goat TSEs is expanding to more and more parts of the world. |
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GoatBSE is a STREP supported by funding under the 6th Research Framework Programme of the European Union,
EU Contract No. FOOD-CT-36353. This website represents the views of the Authors, not the European Commission.
The Commission is not liable for any use that may be made of the information.
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