Eradicating BSE in goats: International Innovation news
Written by Jan Langeveld   
Monday, 20 February 2012 22:42

The consortium has been interviewed by International Innovation, a monthly journal for decision makers, industry, stakeholders including farming sector. One highlight: "The developments made by GoatBSE will also facilitate the control of TSEs in goats. Scrapie and related infections of single animals currently necessitate the culling of entire herds, the results of which are extremely wasteful, evoke strong public outcry and severely damage the financial prospects of farmers. By reining in the impact of TSEs on goat populations through breeding programmes used to raise prion resistant animals, mass culls can be avoided. Thanks to GoatBSE, both consumers and producers will eventually benefit from healthier herds."

Visits to the goat TSE site
Written by administrator   
Tuesday, 04 January 2011 16:37
The public website enjoys a frequent visitors history. It has increased from around 300 visits in 2009 to over 600 in 2010, and in November 2012 to over 1400. Click on the map at the home site that is showing from which sites and countries this interest for goat TSEs is coming from. If you have questions from a goat breeder's situation or from  scientific or decision makers interest, you can approach us on our contact address.
Prion2012 conference registration open!
Written by Alex Bossers   
Tuesday, 22 November 2011 23:55



The Prion2012 international conference 9-12 May 2012 registration is now open. The conference will be hosted in Amsterdam the Netherlands. Come and join us to make this a wonderful event; register now at www.prion2012.com

As in the previous years, there will be again a pre-conference workshop dedicated to Animal TSEs.




New paper on goat PrP polymorphisms association
Written by Alex Bossers   
Friday, 02 December 2011 11:06
A new publication is out by Goldmann et al. in Veterinary Research that originated from this project on "the association of goat PrP polymorphisms with decreased scrapie susceptibility in UK goat breeds". A collaborative study with contributors from the UK, Mexico, and NL. The paper describes/supports the association of Met142 with decreased susceptibility to scrapie in goats and the suppresive effect of Ser127 on the clinical expression of disease.
Prion protein allele frequencies in Europe
Written by Jan Langeveld   
Tuesday, 25 October 2011 21:57

One of the tasks of the GoatBSE project has been to study the PrP coding region variation in order to evaluate the presence of alleles which influence the susceptibility of goats to TSE. Several caprine PrP polymorphisms have been published, the most common of which are in codons 142, 154, 211, 222 and 240 (see figures below). It is likely that analysing a larger number of samples from EU breeds would reveal further polymorphisms. We therefore collected samples for analysing the PrP coding region of roughly 6000 samples. These samples originated from several countries, collected from the most common breeds (eg. Saanen, Alpine) as well as some rare goat breeds. Genomic DNA was produced from blood/tissue samples. The PrP coding region was sequenced in full by direct sequencing of PCR-generated DNA.
The results are displayed in the
pdf file. If you are using these data, please refer to EU project GoatBSE FOOD-CT-2006-36353, coordinator Alex Bossers, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands.



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